KOENVENEMA

 

 

Koen Venema, PhD

 

 

My Publications  

(pdf available upon request; go to end of this page and fill out the form)

 


# of publications (double refereed and book chapters):  124
# of publications with citations:                                  102
total # of citations (Google scholar):                         6177
h-index (Google scholar):                                           43
i10-index (Google scholar):                                         86

last updated on August 08, 2017 


124. Keller D, Van Dinter R, Cash H, Farmer S, Venema K. 2017. Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (TIM-1). Benef Microbes. 8(3):491-496 - Link to full paper

123. Canfora EE, van der Beek CM, Hermes GDA, Goossens GH, Jocken JWE, Holst JJ, van Eijk HM, Venema K, Smidt H, Zoetendal EG, Dejong CHC, Lenaerts K, Blaak EE. 2017. Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals. Gastroenterology. 153(1):87-97.e3 - Link to full paper

122. Aguirre M, Venema K. 2017. Challenges in simulating the human gut for understanding the role of the microbiota in obesity. Benef Microbes. 8(1):31-53 - Link to full paper

121. Neis EP, Bloemen JG, Rensen SS, van der Vorst JR, van den Broek MA, Venema K, Buurman WA, Dejong CH. 2016. Effects of Liver Resection on Hepatic Short-Chain Fatty Acid Metabolism in Humans. PLoS One. 11(11):e0166161 - Link to full paper

120. Aguirre M, Bussolo de Souza C, Venema K. 2016. The Gut Microbiota from Lean and Obese Subjects Contribute Differently to the Fermentation of Arabinogalactan and Inulin. PLoS One. 11(7):e0159236 - Link to full paper

119. Rösch C, Taverne N, Venema K, Gruppen H, Wells JM, Schols HA. 2017. Effects of in vitro fermentation of barley β-glucan and sugar beet pectin using human fecal inocula on cytokine expression by dendritic cells. Mol Nutr Food Res. 61(1).doi: 10.1002/mnfr.201600243 - Link to full paper

118. Koenen M.E., Cruz Rubio J.M, Mueller M. and Venema K. 2016. The effect of agave fructan products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine. J Functional Foods, 22: 201-10. - Link to full paper

117. Kortman G.A.M., Dutilh B.E., Maathuis A.J.H., Engelke U.F., Boekhorst J., Keegan K.P., Ginn Nielsen F.G., Betley J., Weir J.C., Kingsbury Z, Kluijtmans L.A.J., Swinkels D.W., Venema K. and Tjalsma H. Microbial metabolism shifts towards an adverse profile with supplementary iron in the TIM-2 in vitro model of the human colon. Frontiers in Microbiology, 6:1481. doi: 10.3389/fmicb.2015.01481. - Link to full paper

116. Aguirre M, Eck A, Koenen ME, Savelkould P.H.M., Budding A.E.,  Venema K. 2016. Diet drives quick changes in the metabolic activity and composition of human gut microbiota in a validated in vitro gut model. Res Microbiol 167(2): 114-25. doi:10.1016/j.resmic.2015.09.006 - Link to full paper

115. Aguirre M, Eck A, Koenen ME, Savelkoul PH, Budding AE, Venema K (2015) Evaluation of an optimal preparation of human standardized fecal inocula for in vitro fermentation studies. J Microbiol Methods; 117:78-84. doi: 10.1016/j.mimet.2015.07.019 - Link to full paper

114. Venema K. 2015. Health Effects of Pro­ and Prebiotics: Utilization of Sophisticated In Vitro Tools. In: Beneficial Microorganisms in Medical and Health Applications; Series: Microbiology Monographs, Vol. 28; M.-T. Liong (Ed.) 2015. ISBN: 978-3-319-23212-6. Chapter 1; pp. 1-18. - Link to full paper

113. Rösch C, Venema K, Gruppen H, Schols HA. 2015. Characterisation and in vitro fermentation of resistant maltodextrins using Human faecal inoculum and analysis of bacterial enzymes present. Bioactive Carbohydrates and Dietary Fibre 6(1): 46-53. - Link to full paper

112. Schnorr SL, Crittenden AN, Venema K, Marlowe F, Henry AG. 2015. Assessing digestibility of Hadza tubers using a dynamic in-vitro model. American Journal of Physical Anthropology 158(3): 371-85. - Link to full paper

111. van der Beek CM, Bloemen JG, van den Broek MA, Venema K, Buurman WA, Dejong CH. 2015. Hepatic uptake of rectally administered butyrate prevents an increase in systemic butyrate concentrations in humans. Journal of Nutrition. in press. doi: 10.3945/jn.115.211193 - Link to full paper

110. Aguirre M and Venema K. 2015. The use of fecal samples for studying human obesity. European Journal of Epidemiology 30(9): 1067-9. DOI 10.1007/s10654-015-0048-z - Link to full paper

109. Aguirre M and Venema K. 2015. The art of targeting gut microbiota for tackling human obesity. Genes & Nutrition 2015; 10:20. - Link to full paper

108. Aguirre M and Venema K. 2015. Does the gut microbiota contribute to obesity? Going beyond the gut feeling. Microorganisms 3(2), 213-235. - Link to full paper

107. Nalin T, Sperb-Ludwig F, Venema K, Derks TGJ, Schwartz IVD. 2015. Determination of amylose/amylopectin ratio of starches. Journal of Inherited Metabolic Disease. 38(5): 985-6. DOI: 10.1007/s10545-015-9850-8. - Link to full paper

106. Guida S and Venema K. Gut microbiota and obesity: Involvement of the adipose tissue. J Functional Foods 2015; 14:40-7-23. - Link to full paper

105. Venema K and do Carmo AP. 2015. Probiotics and prebiotics: current status and future trends. In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 1; pp. 3-12. - Link to full paper

104. Venema K and Meijerink M. 2015. Lactobacilli as probiotics: discovering new functional aspects and target sites. In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 3; pp. 29-42. - Link to full paper

103. Venema K. 2015. Functional aspects of the endogenous microbiota that benefit the host. In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 15; pp. 221-34. - Link to full paper

102. Frøkiær H, Broeng Metzdorff S and Venema K. 2015. Immunomodulating effects of prebiotics and fibres. In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 21; pp. 315-30. - Link to full paper

101. Venema K. 2015. Synbiotics – more than just the sum of pro- & prebiotics? In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 23; pp. 345-60. - Link to full paper

100. Venema K and do Carmo AP. 2015. Is the sky the limit? In: Probiotics and Prebiotics: Current Research and Future Trends. Venema K and do Carmo AP (eds). Caister Academic Press, UK. ISBN: 978-1-910190-09-8; Chapter 33; pp. 489-94. - Link to full paper

99. Vogt L, Meyer D, Pullens G, Faas M, Smelt M, Venema K, Ramasamy U, Schols HA, de Vos P. Immunological properties of inulin-type fructans. Crit Rev Food Sci Nutr.  2015; 55(3):414-36 - Link to full paper

98. Bussolo de Souza C, Roeselers G, Troost F, Jonkers D, Koenen ME, Venema K. Prebiotic effects of cassava bagasse in TNO's in vitro model of the colon in lean versus obese microbiota. Journal of Functional Foods. 2014;Volume 11, 210–220. - Link to full paper

97. Aguirre M, Jonkers DM, Troost FJ, Roeselers G, Venema K. In vitro characterization of the impact of different substrates on metabolite production, energy extraction and composition of gut microbiota from lean and obese subjects. PLoS One. 2014 Nov 26;9(11):e113864. - Link to full paper

96. Nalin T, Venema K, Weinstein DA, de Souza CFM, Perry IDS, van Wandelen MTR, van Rijn M, Smit GPA, Schwartz IVD, Derks TGJ. 2014. In vitro digestion of starches in a dynamic gastrointestinal model: an innovative study to optimize dietary management of patients with hepatic glycogen storage diseases. Journal of Inherited Metabolic Disease - 2015 38(3): 529-36 [Epub online in 2014]. - Link to full paper

95. Aguirre M, Ramiro-Garcia J, Koenen ME, Venema K. To pool or not to pool? Impact of the use of individual and pooled fecal samples for in vitro fermentation studies. J Microbiol Methods. 2014 Sep 3;107:1-7. doi: 10.1016/j.mimet.2014.08.022 . - Link to full paper

94. Lefebvre DE, Venema K, Gombau L, Valerio LG Jr, Raju J, Bondy GS, Bouwmeester H, Singh RP, Clippinger AJ, Collnot EM, Mehta R, Stone V. Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices. Nanotoxicology 2015; 9(4):523-42. [Epub online in 2014]. - Link to full paper

93. Ramasamy US, Venema K, Gruppen H,Schols HA. The fate of chicory root pulp polysaccharides during fermentation in the TNO in vitro model of the colon (TIM-2). Bioactive Carbohydrates & Dietary Fibre. 2014;4(1):48-57. - Link to full paper

92. Ramasamy US, Venema K, Schols HA, Gruppen H. The effect of soluble and insoluble fibers within the in vitro fermentation of chicory root pulp by human gut bacteria. J Agric Food Chem. 2014;62(28):6794-802. - Link to full paper

91. Venema, K. (2014) In Vitro Assessment of the Bioactivity of Food Oligosaccharides. In: Food Oligosaccharides - Production, Analysis and Bioactivity. Moreno, J.F. and Sanz M.L. (Eds). John Wiley & Sons Ltd, Chichester, UK. pp.219-37. - Link to full paper

90. Vogt LM, Meyer D, Pullens G, Faas MM, Venema K, Ramasamy U, Schols HA, de Vos P. Toll-Like Receptor 2 Activation by β2→1-Fructans Protects Barrier Function of T84 Human Intestinal Epithelial Cells in a Chain Length-Dependent Manner. J Nutr. 2014; 144(7):1002-8. - Link to full paper

89. Reimer RA, Maathuis AJH, Venema K, Lyon MR, Gahler RJ and Wood S. Effect of the Novel Polysaccharide PolyGlycopleX® on Short-Chain Fatty Acid Production in a Computer-Controlled in Vitro Model of the Human Large Intestine. Nutrients 2014; 6: 1115-27. - Link to full paper

88. Leijdekkers A, Aguirre M, Venema K, Bosch G, Gruppen H, Schols HA. In Vitro Fermentability of Sugar Beet Pulp Derived Oligosaccharides Using Human and Pig Fecal Inocula. J Agric Food Chem. 2014; 62(5):1079-87. - Link to full paper

87. Bordonaro M, Venema K, Putri AK, Lazarova DL. Approaches that ascertain the role of dietary compounds in colonic cancer cells. World J Gastrointest Oncol. 2014; 6(1): 1-10. - Link to full paper

86. Blatchford P, Ansell J, de Godoy MRC, Fahey G, Garcia-Mazcorro JF, Gibson GR, Goh YJ, Hotchkiss AT, Hutkins R, LaCroix C, Rastall RA, Reimer RA, Schoterman M, Van Sinderen D, Venema K, Whelan K. Prebiotic mechanisms, functions and applications - A review. Intl J Probiotics Prebiotics. 2013 8(4). - Link to full paper

85. Van den Abbeele P, Venema K, Van de Wiele T, Verstraete W, Possemiers S.Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan versus Inulin.J Agric Food Chem. 2013 Oct 16;61(41):9819-27. - Link to full paper

84. Vogt L, Ramasamy U, Meyer D, Pullens G, Venema K, Faas MM, Schols HA, de Vos P. Immune Modulation by Different Types of β2→1-Fructans Is Toll-Like Receptor Dependent.PLoS One. 2013 Jul 5;8(7):e68367. - Link to full paper

83. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism.J Lipid Res. 2013 Sep; 54(9):2325-40. - Link to full paper

82. Venema K, van den Abbeele P.Experimental models of the gut microbiome. Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):115-26. - Link to full paper

81. Keszthelyi D, Troost FJ, Jonkers DM, Helyes Z, Hamer HM, Ludidi S, Vanhoutvin S, Venema K, Dekker J, Szolcsányi J, Masclee AA. Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: A role in pain symptom generation? Eur J Pain. 2013 Oct;17(9):1299-306. - Link to full paper

80. Sybesma W, Molenaar D, van Ijcken W, Venema K, Kort R. Genome instability in Lactobacillus rhamnosus GG. Appl Environ Microbiol. 2013;79(7):2233-9. - Link to full paper

79. Ruiz Martinez RC, Cardarellia HR, Borst W, Albrecht S, Schols H, Pérez Gutiérrez O, Maathuis AJH, Gombossy de Melo Franco BD, Pereira De Martinis EC, Zoetendal EG, Venema K, Isay Saad SM, Smidt H. Effect of galactooligosaccharides and Bifidobacterium animalis Bb-12 on growth of Lactobacillus amylovorus DSM 16698, microbial community structure, and metabolite production in an in vitro colonic model set up with human or pig microbiota. FEMS Microbiol Ecol. 2013; 84(1):110-23. - Link to full paper

78. Hatanaka M, Nakamura Y, Maathuis AJ, Venema K, Murota I, Yamamoto N. Influence of Bacillus subtilis C-3102 on microbiota in a dynamic in vitro model of the gastrointestinal tract simulating human conditions. Benef Microbes. 2012 Sep;3(3):229-36. - Link to full paper

77. Meijerink M, Wells JM, Taverne N, de Zeeuw Brouwer ML, Hilhorst B, Venema K, van Bilsen J. Immunomodulatory effects of potential probiotics in a mouse peanut sensitization model. FEMS Immunol Med Microbiol. 2012 Aug;65(3):488-96. - Link to full paper

76. Mäkivuokko H, Wacklin P, Koenen ME, Laamanen K, Alakulppi N, Venema K, Mättö J. Isolation of bifidobacteria for blood group secretor status targeted personalised nutrition. Microbial Ecology Health Dis. 2012; 23: 18578 - Link to full paper

75. Maathuis AJH, van den Heuvel EG, Schoterman MHC, Venema K. Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a 13C labeling technique. J Nutr. 2012 Jul;142(7):1205-12. - Link to full paper

74. Venema K. Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides. 2012 Int Dairy J. 22 (2); 123-40. - Link to full paper

73. Rehman A, Heinsen FA, Koenen M, Venema K, Knecht H, Hellmig S, Schreiber S, Ott SJ. Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. BMC Microbiol. 2012 Mar 27;12(1):47. - Link to full paper

72. Vanhoutvin SA, Troost FJ, Kilkens TO, Lindsey PJ, Jonkers DM, Venema K, Masclee A, Brummer RJ. Alternative procedure to shorten rectal barostat procedure for the assessment of rectal compliance and visceral perception: a feasibility study. J Gastroenterol. 2012 Aug;47(8):896-903. - Link to full paper

71. Al-Lahham S, Roelofsen H, Rezaee F, Weening D, Hoek A, Vonk R, Venema K. Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects. Eur J Clin Invest. 2012 Apr;42(4):357-64. - Link to full paper

70. Venema, K. Stable isotope probing of the human gut. In Stable isotope probing and related technologies. Murrell, J.C. and Whiteley A.S. (editors) 2011; pp 233-257. - Link to full paper

69. Tabernero M, Venema K, Maathuis AJ, Saura-Calixto FD. Metabolite Production during in Vitro Colonic Fermentation of Dietary Fiber: Analysis and Comparison of Two European Diets. J Agric Food Chem. 2011; 59(16):8968-75. - Link to full paper

68. Martinez RC, Aynaou AE, Albrecht S, Schols HA, De Martinis EC, Zoetendal EG, Venema K, Saad SM, Smidt H. In vitro evaluation of gastrointestinal survival of Lactobacillus amylovorus DSM 16698 alone and combined with galactooligosaccharides, milk and/or Bifidobacterium animalis subsp. lactis Bb-12. Int J Food Microbiol. 2011 Sep 15;149(2):152-8. - Link to full paper

67. Binsl TW, De Graaf AA, Venema K, Heringa J, Maathuis A, De Waard P, Van Beek JH. Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. Benef Microbes. 2010 Nov;1(4):391-405. - Link to full paper

66. Zhu Y, Havenaar R, Venema K. Re: Pitino et al. (2010) Food Microbiology 27:1121-1127 "Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract". Food Microbiol. 2011 Aug;28(5):1110. - Link to full paper

65. Rajilić-Stojanović M, Maathuis A, Heilig HG, Venema K, de Vos WM, Smidt H. Evaluating the microbial diversity of an in vitro model of the human large intestine by phylogenetic microarray analysis. Microbiology. 2010 Nov;156(Pt 11):3270-81. - Link to full paper

64. Al-Lahham SH, Peppelenbosch MP, Roelofsen H, Vonk RJ, Venema K. Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta. 2010 Nov; 1801(11):1175-83. - Link to full paper

63. Venema, K. Impact of fiber on gastrointestinal microbiota. In Nondigestible Carbohydrates and Digestive Health. Paeschke, T.M. and Aimutis W.R. (editors), 2010; pp. 125-164. - Link to full paper

62. Venema, K. Role of gut microbiota in the control of energy and carbohydrate metabolism. Curr Opinion Clin Nutr Metabol Care 2010 Jul;13(4):432-8. - Link to full paper

61. Venema, K., de Graaf, A.A., Maathuis, A.J.H., Kovatcheva-Datchary, P., and Smidt, H. Fermentation in the large intestine unraveled using 13C-labeled substrates! – Implications for obesity and gut health. (2010) In Dietary fibre: new frontiers for food and health. Van der Kamp, J.-W., Jones, J.M., McCleary, B.V., and Topping, D.L. (editors); Wageningen Academic Publishers; pp 539-554. - Link to full paper

60. Maathuis, A., A. Hoffman, A. Evans, L. Sanders and K. Venema. The effect of the undigested fraction of maize products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine. 2009 Dec;28(6):657-66. - Link to full paper

59. Hamer HM, Jonkers DM, Vanhoutvin SA, Troost FJ, Rijkers G, de Bruïne A, Bast A, Venema K, Brummer RJ. Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission. Clin Nutr. 2010 Dec;29(6):738-44. - Link to full paper

58. Hamer HM, Jonkers DM, Renes IB, Vanhoutvin SA, Kodde A, Troost FJ, Venema K, Brummer RJ. Butyrate enemas do not affect human colonic MUC2 and TFF3 expression. Eur J Gastroenterol Hepatol. 2010 Sep;22(9):1134-40. - Link to full paper

57. Al-Lahham SH, Roelofsen H, Priebe M, Weening D, Dijkstra M, Hoek A, Rezaee F, Venema K, Vonk RJ. Regulation of adipokine production in human adipose tissue by propionic acid. Eur J Clin Invest. 2010 May;40(5):401-7. - Link to full paper

56. Maathuis, A. J.H, D. Keller and S. Farmer. Survival and metabolic activity of the GanedenBC30 strain of Bacillus coagulans in a dynamic in vitro model of the stomach and small intestine. Beneficial Microbes 2010; 1(1): 31-36. - Link to full paper

55. Rose DJ, Venema K, Keshavarzian A, Hamaker BR. Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease. Br J Nutr. 2010 May;103(10):1514-24. - Link to full paper

54. Bloemen JG, Olde Damink SW, Venema K, Buurman WA, Jalan R, Dejong CH. Short chain fatty acids exchange: Is the cirrhotic, dysfunctional liver still able to clear them? Clin Nutr. 2010 Jun;29(3):365-9. - Link to full paper

53. Vanhoutvin SA, Troost FJ, Hamer HM, Lindsey PJ, Koek GH, Jonkers DM, Kodde A, Venema K, Brummer RJ. Butyrate-induced transcriptional changes in human colonic mucosa. PLoS One. 2009 Aug 25;4(8):e6759. - Link to full paper

52. de Graaf AA, Maathuis A, de Waard P, Deutz NE, Dijkema C, de Vos WM, Venema K. Profiling human gut bacterial metabolism and its kinetics using [U-13C]glucose and NMR. NMR Biomed. 2010 Jan;23(1):2-12. - Link to full paper

51. Kovatcheva-Datchary, P., E. G. Zoetendal, K. Venema, W. M. de Vos, and H. Smidt. Review: Tools for the tract: understanding the functionality of the gastrointestinal tract. Therapeutic Advances in Gastroenterology, July 1, 2009; 2(4_suppl): s9 - s22. - Link to full paper

50. Bloemen JG, Venema K, van de Poll MC, Olde Damink SW, Buurman WA, Dejong CH. Short chain fatty acids exchange across the gut and liver in humans measured at surgery. Clin Nutr. 2009 Dec;28(6):657-61. - Link to full paper

49. Vanhoutvin SA, Troost FJ, Kilkens TO, Lindsey PJ, Hamer HM, Jonkers DM, Venema K, Brummer RJ. The effects of butyrate enemas on visceral perception in healthy volunteers. Neurogastroenterol Motil. 2009 Sep;21(9):952-e76. - Link to full paper

48. Hamer HM, Jonkers DM, Loof A, Vanhoutvin SA, Troost FJ, Venema K, Kodde A, Koek GH, Schipper RG, van Heerde WL, Brummer RJ. Analyses of human colonic mucus obtained by an in vivo sampling technique. Dig Liver Dis. 2009 Aug;41(8):559-64. - Link to full paper

47. Kovatcheva-Datchary P, Egert M, Maathuis A, Rajilić-Stojanović M, de Graaf AA, Smidt H, de Vos WM, Venema K. Linking phylogenetic identities of bacteria to starch fermentation in an in vitro model of the large intestine by RNA-based stable isotope probing. Environ Microbiol. 2009 Apr;11(4):914-26. - Link to full paper

46. Hamer HM, Jonkers DM, Bast A, Vanhoutvin SA, Fischer MA, Kodde A, Troost FJ, Venema K, Brummer RJ. Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Clin Nutr. 2009 Feb;28(1):88-93. - Link to full paper

45. Kong H, Wang M, Venema K, Maathuis A, van der Heijden R, van der Greef J, Xu G, Hankemeier T. Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. J Chromatogr A. 2009 Mar 13;1216(11):2195-203. - Link to full paper

44. He T, Venema K, Priebe MG, Welling GW, Brummer RJ, Vonk RJ. The role of colonic metabolism in lactose intolerance. Eur J Clin Invest. 2008 Aug;38(8):541-7. - Link to full paper

43. Hamer, H, Jonkers, D, Venema, K, Vanhoutvin, S, Troost, F, Brummer, R-J. Role of short chain fatty acids – mainly butyrate – on colonic epithelial function. Alimentary Pharmacology and Therapeutics 2007 28:104–119. - Link to full paper

42. Meesters, RJW, van Eijk, HMH, ten Have, GAM, de Graaf, AA, Venema, K, van Rossum, BEJ and Deutz, NEP. Application of liquid chromatography–mass spectrometry to measure the concentrations and study the synthesis of short chain fatty acids following stable isotope infusions. J Chrom B. 2007 854:57–62. - Link to full paper

41. Venema, K, de Graaf, AA, Deutz, NEP. Metabolic conversions of dietary carbohydrates by gut microbes. In Proceedings of DF2006, Dietary Fibre components and functions. Eds. H. Salovaara, F. Gates & M. Tenkanen. 2007 pp 145-156. - Link to full paper

40. de Graaf, AA, Venema, K. Gaining insight in microbial physiology in the large intestine: a special role for stable isotopes. Adv Microb Physiol. 2007 53: 73-168. - Link to full paper

39. Egert, M, de Graaf, AA, Maathuis, A, de Waard, P, Plugge, CM, Smidt, H, Deutz, NEP, Dijkema, C, de Vos, WM, Venema, K. Identification of glucose-fermenting bacteria present in an in-vitro model of the human intestine by RNA-stable isotope probing. FEMS Microbiol Ecol. 60:126-135. - Link to full paper

38. He,T, Roelofsen, H, Alvarez-Llamas, G, de Vries, M, Venema, K, Welling, GW, Vonk, RJ. Differential analysis of protein expression of Bifidobacterium grown on different carbohydrates. J Microbiol Meth 69:364-370. - Link to full paper

37. C. Fässler, E. Arrigoni, K. Venema, F. Brouns, R. Amadò. (2006) In vitro fermentability of differently digested resistant starch preparations. Mol. Nutr. Food Res. 50: 1220–1228. - Link to full paper

36. C. Fässler, E. Arrigoni, K. Venema, V. Hafner, F. Brouns, R. Amadò. (2006) Digestibility of resistant starch containing preparations using two in vitro models. Eur J Nutr. 45(8): 445-453. - Link to full paper

35. Egert, M. de Graaf, A.A. Smidt, H. de Vos, W.M. and Venema, K. (2006) Beyond diversity - functional microbiomics for the human colon. Trends Microbiol 14: 86-91. - Link to full paper

34. Gao, K., Xu, A., Krul, C., Venema, K., Liu, Y., Niu, Y., Lu, J., Bensoussan, L., Seeram, N.P., Heber, D. and Henning, S.M. (2006). Of major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements. Only 3,4-dihydroxyphenylacetic acid has antiproliferative activity. J. Nutr. 136: 52-57. - Link to full paper

33. Van Nuenen, M., de Ligt, R.A., Doornbos, R.P., Venema, K., Van der Woude, C.J., and Kuipers, E.J. (2005). The influence of microbial metabolites on human intestinal epithelial cells and macrophages in vitro. FEMS Immunol Med Microbiol 45(2):183-9. - Link to full paper

32. K. Venema, SHF Vermunt, EJ Brink. 2005). D-Tagatose increases butyrate production by colonic microbiota in healthy men and women. Microbial Ecology Health Dis. 17: 47-57. - Link to full paper

31. K. Venema, JJM. van de Sandt and R. Havenaar (2004) In vitro techniques and ex vivo systems for studying the metabolism of intestinal bacteria. J. Intest. Microbiol. June 15-17. - Link to full paper

30. Čanžek Majhenič, K. Venema, GE. Allison, B. Bogovič Matijašić, I. Rogelj, TR. Klaenhammer (2004). DNA analysis of the genes encoding acidocin LF221 A and acidocin LF221 B, two peptide bacteriocins produced by Lactobacillus gasseri LF221. Appl. Microbiol. Biotechnol. 63: 705-714. - Link to full paper

29. H.M.C. van Nuenen, K. Venema, JCJ. van der Woude, EJ. and Kuipers (2004). The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease. Digestive Disease and Sciences 49 (3): 485-491. - Link to full paper

28. Venema, K., Minekus, M. and Havenaar, R. (2004) Advanced in vitro models of the gastro-intestinal tract: Novel tools to study functionallity of dietary fibres. In: Dietary Fibre. Bio-active carbohydrates for food and feed. Eds. J.W. van der Kamp et al. Wageningen Academic Publishers. pp 99-112. - Link to full paper

27. D. Meyer, M. Van Nuenen, K. Venema (2004) The effect of various inulins and Clostridium difficile on the metabolic activity and composition of the human colonic microbiota in vitro. In: dietary Fibre. Bio-active carbohydrates for food and feed. Eds. J.W. van der Kamp et al. Wageningen Academic Publishers. pp 237-253. - Link to full paper

26. K. Venema, M. van Nuenen, E. van de Heuvel, W. Pool and J. van der Vossen (2003). The effect of lactulose on the composition of the intestinal microbiota and short-chain fatty acid production in human volunteers and a computer-controlled model of the proximal large intestine. Microbial Ecology in Health and Disease, 15 (2-3): 94-105. - Link to full paper

25. HMC. van Nuenen, PD. Meyer and  K. Venema (2003). The effect of various inulins and Clostridium difficile on the metabolic activity of the human colonic microbiota in vitro. Microbial Ecology in Health and Disease 15 (2-3): 137–144. - Link to full paper

24. RJ. Lamers, E. Wessels, J. van de Sandt, K. Venema, G. Schaafsma, J van der Greef,  and J. van Nesselrooij (2003). A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting. J. Nutr. 133: 3080-3084. - Link to full paper

23. K. Venema, A. Maathuis.(2003). A PCR-based method for identification of bifidobacteria from the human alimentary tract at the species level. FEMS Microbiol Letters 224(1) 143-149. - Link to full paper

22. JW. Van der Kamp, S. Goldbohm, S. Heimovaara,  H. Mol, R. Stierum, G. Schaafsma, and K. Venema (2003) How to integrate the health dimension into the strategies of agricultural innovation? Proceedings of The 2nd Agrosanté forum “From Healthy Eating . . to Healthy Farming”. Beauvais, France. Published on CD-Rom.

21. K. Venema and H. van de Sandt. (2003) Interaction between food components, intestinal microbiota and intestinal mucosa as a function of intestinal health. AgroFoods 14 (March/April): 62-66. - Link to full paper

20. K. Venema, J. Van Nesselrooij,  R-J Lamers, J. van de Sandt. (2003) Metabolomics of Caco-2 cells: Effect of inulin and its fermentative metabolites. Nutrafood 2(1): 5-12. - Link to full paper

19. I. Stergiopoulos, MMC. Gielkens, SD. Goodall, K. Venema, MA. de Waard. (2002) Molecular cloning and characterisation of three new ATP-binding cassette transporter genes from the wheat pathogen Mycosphaerella graminicola. Gene 289 (1-2): 141-149. - Link to full paper

18. K. Venema and H. van de Sandt (2002). Interaction between food components, intestinal microbiota and intestinal mucosa as a function of intestinal health. Inn. Food Technol, Nov: 55-58. - Link to full paper

17. E. Zeijdner, R. Havenaar, K. Venema and M. Minekus (2002). TIM, an advanced model for testing dissolution from drug delivery systems simulating dynamic conditions in the GI tract. In: Proceedings of Pharmaceutics and drug delivery conference; AAPS, Arlington USA. pp 85-86.

16. MJ. van der Werf and K. Venema (2001). Bifidobacteria: genetic modification and the study of their role in the colon.  J. Agric. Food Chem. 49: 378 383. - Link to full paper

15. D. Demeyer, M. Raemaekers, A. Rizzo, A. Holck, A. De Smedt, B. ten Brink, B. Hagen, C. Montel, E. Zanardi, E. Murbrekk, F. Leroy, F. Vandendriessche, K. Lorentsen, K. Venema, L. Sunesen, L. Stahnke, L. De Vuyst, R. Talon, R. Chizzolini and S. Eerola. (2000) Control of bioflavour and safety in fermented sausages: First results of a European project. Food Research International 33(3-4): 171-180. - Link to full paper

14. K. Venema, HMC. Van Nuenen, MJE. Smeets Peeters, M. Minekus, and R. Havenaar (2000). TNO's in vitro large intestinal model: an excellent screeening tool for functional food and pharmaceutical research. Ernährung/Nutrition 24 (12): 558 564. - Link to full paper

13. H. W. van Veen, K. Venema, H. Bolhuis, I. Oussenko, J. Kok, B. Poolman, A.J.M. Driessen and W.N. Konings. 1996. Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. PNAS USA. 93: 10668-10672. - Link to full paper

12. J. Kok, K. Venema and G. Venema. 1995. Analysis of lactococcin secretion and immunity in Lactococcus lactis. In Developments in Biological  Standardization, Vol. 85: Genetics of Streptococci, Enterococci and Lactococci. J.J. Ferretti, M.S. Gilmore, T.R. Klaenhammer and F. Brown (Eds.), Karger AG, Basel,  Switserland, pp. 653-659. - Link to full paper

11. M. L. Chikindas, K. Venema, A.M. Ledeboer, G. Venema and J. Kok. 1995. Expression of lactococcin A and pediocin PA-1 in heterologous hosts. Lett. Appl. Microbiol. 21: 183-189. - Link to full paper

10. B. Mayo, K. Venema, W. Bockelman, M. Teuber, H. Reinke and G. Venema. 1991. Molecular cloning and sequence analysis of the X-prolyl dipeptidyl aminopeptidase gene from Lactococcus lactis subsp. cremoris. Appl. Environ. Microbiol. 57: 38-44. - Link to full paper

9. C. M. Franke, K.J. Leenhouts, A.J. Haandrikman, J. Kok, G. Venema and *K. Venema. 1996. Topology of LcnD, a protein implicated in the transport of bacteriocins from Lactococcus lactis. J. Bacteriol. 178: 1766-1769. - Link to full paper

8. K. Venema, M.H.R. Dost, P.A.H. Beun, A.J. Haandrikman, G. Venema and J.Kok. 1996. The genes for secretion and maturation of lactococcins are located on the chromosome of Lactococcus lactis IL1403. Appl. Environm. Microbiol. 62: 1689-1692. - Link to full paper

7. K. Venema, M.H.R. Dost, G. Venema and J. Kok. 1996. Mutational analysis and chemical modification of Cys24 of lactococcin B, a bacteriocin produced by Lactococcus lactis. Microbiology 142: 2825-2830. - Link to full paper

6. K. Venema, M.L. Chikindas, J.F.M.L. Seegers, A.J. Haandrikman, G. Venema and J. Kok. 1997. Rapid and efficient purification method for small, hydrophobic, cationic bacteriocins: purification of lactococcin B and pediocin PA-1. Appl. Environ. Microbiol. 63: 305-309. - Link to full paper

5. K. Venema, G. Venema and J. Kok. 1995. Lactococcins: mode of action, immunity and secretion. Int. Dairy J. 5: 815-832. - Link to full paper

4. K. Venema, G. Venema and J. Kok. 1995 Lactococcal bacteriocins: mode of action and immunity. Trends in Microbiol. 3: 299-304. - Link to full paper

3. K. Venema, J. Kok, J.D. Marugg, M.Y. Toonen, A.M. Ledeboer, G. Venema and M.L. Chikindas.1995. Functional analysis of the pediocin operon of Pediococcus acidilactici PAC1.0: PedB is the immunity protein and PedD is the precursor processing enzyme. Mol. Microbiol. 17: 515-522. - Link to full paper

2. K. Venema, R.E. Haverkort, T. Abee, A.J. Haandrikman, K.J. Leenhouts, L. de Leij, G. Venema and J. Kok. 1994. Mode of action of LciA, the lactococcin A immunity protein. Mol. Microbiol. 14: 521-532. - Link to full paper

1. K. Venema, T. Abee, A.J. Haandrikman, K.J. Leenhouts, J. Kok, W.N. Konings and G. Venema. 1993. Mode of action of lactococcin B, a thiol-activated bacteriocin from Lactococcus lactis. Appl. Environm. Microbiol. 59: 1041-1048. - Link to full paper